Vertex Pharmaceuticals
Q4 2022 Earnings Call
Feb 07, 2023, 4:30 p.m. ET
Contents:
- Prepared Remarks
- Questions and Answers
- Call Participants
Prepared Remarks:
Operator
Good day, and welcome to the Vertex Pharmaceuticals fourth quarter and full year 2022 conference call. [Operator instructions] Please note this event is being recorded. I would now like to turn the conference over to Ms. Susie Lisa.
Please go ahead.
Susie Lisa -- Vice President, Investor Relations
Good evening, everyone. My name is Susie Lisa, and as the senior vice president of investor relations for Vertex, it is my pleasure to welcome you to our fourth quarter and full year 2022 financial results conference call. On tonight's call, making prepared remarks, we have Dr. Reshma Kewalramani, Vertex' CEO and president; Stuart Arbuckle, chief operating officer; and Charlie Wagner, chief financial officer.
We recommend that you access the webcast slides as you listen to this call. The call is being recorded, and a replay will be available on our website. We will make forward-looking statements on this call that are subject to the risks and uncertainties discussed in detail in today's press release and in our filings with the Securities and Exchange Commission. These statements, including, without limitation, those regarding Vertex' marketed cystic fibrosis medicines, our pipeline, and Vertex' future financial performance are based on management's current assumptions.
Actual outcomes and events could differ materially. I would also note that select financial results and guidance that we will review on the call this evening are presented on a non-GAAP basis. In addition, the impact of the foreign exchange is presented inclusive of our foreign exchange risk management program. I'll now turn the call over to Reshma.
Reshma Kewalramani -- Chief Executive Officer and President
Thanks, Susie. Good evening all, and thank you for joining us on the call today. We are pleased to have closed out a strong 2022 with full year global CF product revenue up 18% versus 2021. Our full year 2023 product revenue guidance is $9.55 billion to $9.7 billion, representing 7% to 9% growth year on year, inclusive of FX headwind of approximately 1.5%.
We have more than 20,000 patients still to reach with CFTR modulators, and we continue to work with focus and urgency to reach all patients with CF around the globe who may benefit from our therapies. It is an exciting time for Vertex. Our medicines have transformed CF, and the growth of our CF business has transformed Vertex. Our differentiated R&D approach led to our multiple life-changing therapies in cystic fibrosis and is designed to deliver transformative medicines for serious diseases at high rates of success, agnostic to modality.