BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) Q2 2024 Earnings Call Transcript August 5, 2024 8:30 AM ET

Company Participants

John Bluth - Chief Communications Officer
Jon Stonehouse - CEO
Charlie Gayer - Chief Commercial Officer
Anthony Doyle - CFO
Helen Thackray - Chief R&D Officer

Conference Call Participants

Tazeen Ahmad - Bank of America
Brian Abrahams - RBC Capital Markets
Chris Raymond - Piper Sandler
Gena Wang - Barclays
Maury Raycroft - Jefferies
Stacy Ku - TD Cowen
Jon Wolleben - JMP Securities
Serge Belanger - Needham & Company

Operator

Good day and welcome to the BioCryst Second Quarter 2024 Earnings Call. All participants will be in listen-only mode. [Operator Instructions] After today's presentation there will be an opportunity to ask questions. [Operator Instructions] Please note this event is being recorded. I would now like to turn the conference over to John Bluth at BioCryst. Please go ahead.

John Bluth

Thanks, Dave. Good morning and welcome to BioCryst second quarter 2024 corporate and financial results conference call. Today's press release and accompanying slides which we'll be referring to, are available on our website. Participating with me today are CEO, Jon Stonehouse; CFO, Anthony Doyle; Chief Commercial Officer, Charlie Gayer; and Chief R&D Officer, Dr. Helen Thackray. Following our remarks, we'll answer your questions.

Today's conference call will contain forward-looking statements including those statements regarding future results, unaudited and forward-looking financial information as well as the company's future performance and/or achievements. These statements are subject to known and unknown risks and uncertainties which may cause our actual results, performance or achievements to be materially different from any future results or performance expressed or implied in this presentation. You should not place undue reliance on these forward-looking statements. For additional information, including a detailed discussion of our risk factors, please refer to the company's documents filed with the Securities and Exchange Commission, which can be accessed on our website.

In addition, today's conference call includes non-GAAP pro forma financial measures. For reconciliation of these non-GAAP measures against the most directly comparable GAAP financial measure, please refer to the earnings press release posted in the press releases section of our investor relations website at www.biocryst.com.

I'd now like to turn the call over to Jon Stonehouse.

Jon Stonehouse

Thanks, John. Our second quarter performance with ORLADEYO is nothing short of amazing, especially when you recall the great start we had in the first quarter. This performance is due to the confidence we are seeing from our customers since late last year and it continues to build. Physicians who treat HAE in many of their patients are experiencing firsthand how well ORLADEYO works and that they can achieve this control with an oral once-daily therapy, efficacy and convenience. Many patients are experiencing efficacy similar to what they had on injectable therapy. As a result, halfway through the fourth year since approval, we are experiencing demand as strong as the start of the launch. Amazing. This confidence has also led us to increase our guidance for the year to between $420 million and $435 million. Charlie will provide more details on the quarter and share why the evidence is increasingly clear we are on a path to $1 million at peak.